1. Human Sensory Neuron-like Cells and Glycated Collagen Matrix as a Model for the Screening of Analgesic Compounds.

Bufalo MC, Almeida MES, Jensen JR, DeOcesano-Pereira C, Lichtenstein F, Picolo G, Chudzinski-Tavassi AM, Sampaio SC, Cury Y, Zambelli VO.

Cells. 2022 Jan 12;11(2):247. doi: 10.3390/cells11020247.

PMID: 35053363 

2. Activation of PKCε-ALDH2 Axis Prevents 4-HNE-Induced Pain in Mice.

Martins BB, Hösch NG, Alcantara QA, Budas GR, Chen CH, Mochly-Rosen D, Ferreira JCB, Zambelli VO.

Biomolecules. 2021 Nov 30;11(12):1798. doi: 10.3390/biom11121798.

PMID: 34944441 

3. PKCζ-Mitogen-Activated Protein Kinase Signaling Mediates Crotalphine-Induced Antinociception.

de Freitas BG, Hösch NG, Pereira LM, Barbosa TC, Picolo G, Cury Y, Zambelli VO.

Toxins (Basel). 2021 Dec 20;13(12):912. doi: 10.3390/toxins13120912.

PMID: 34941749 

4. Pain and Cellular Migration Induced by Bothrops jararaca Venom in Mice Selected for an Acute Inflammatory Response: Involvement of Mast Cells.

Kondo FV, Cabrera WHK, Ribeiro OG, De Franco M, Jensen JR, Picolo G, Sant'Anna MB, Spadafora-Ferreira M, Borrego A, Ibañez OM, Starobinas N.

Front Immunol. 2022 Feb 4;12:779473. doi: 10.3389/fimmu.2021.779473. eCollection 2021.

PMID: 35185861

5. COVID-19 induces proatherogenic alterations in moderate to severe non-comorbid patients: A single-center observational study.

Kimura LF, Sant'Anna MB, Andrade SA, Ebram MC, Lima CFG, Celano RMG, Viégas RFM, Picolo G.

Blood Cells Mol Dis. 2021 Dec;92:102604. doi: 10.1016/j.bcmd.2021.102604. Epub 2021 Sep 9. 

PMID: 34517295

6. How environmental enrichment balances out neuroinflammation in chronic pain and comorbid depression and anxiety disorders.

Kimura LF, Novaes LS, Picolo G, Munhoz CD, Cheung CW, Camarini R. 

Br J Pharmacol. 2022 Apr;179(8):1640-1660. doi: 10.1111/bph.15584. Epub 2021 Jul 1. PMID: 34076891  

7. Crotoxin Inhibits Endothelial Cell Functions in Two- and Three-dimensional Tumor Microenvironment. Kato EE, Pimenta LA, de Almeida MES, Zambelli VO, Dos Santos MF, Sampaio SC. Front Pharmacol. 2021 Aug 4;12:713332. doi:10.3389/fphar.2021.713332. eCollection 2021.PMID: 34421610 

8. Neurotoxicity of Olindias sambaquiensis and Chiropsalmus quadrumanus extracts in sympathetic nervous system. Bueno TC, Collaço RC, Cardoso BA, Bredariol RF, Escobar ML, Cajado IB, Gracia M, Antunes E, Zambelli VO, Picolo G, Cury Y, Morandini AC, Marques AC, Sciani JM, Rocha T. Toxicon. 2021 Aug;199:127-138. doi: 10.1016/j.toxicon.2021.06.008. Epub 2021 Jun 15.PMID: 34139257

9. Alcohol and analgesia: a fine wine getting better with age. Zambelli VO, Alcantara QA, Gross ER. Br J Anaesth. 2021 Aug;127(2):177-181. doi: 10.1016/j.bja.2021.05.003. Epub 2021 Jun 3.PMID: 34090680

10. Box Jellyfish (Cnidaria, Cubozoa) Extract Increases Neuron's Connection: A Possible Neuroprotector Effect. Arruda GLM, Vigerelli H, Bufalo MC, Longato GB, Veloso RV, Zambelli VO, Picolo G, Cury Y, Morandini AC, Marques AC, Sciani JM. Biomed Res Int. 2021 Mar 4;2021:8855248. doi: 10.1155/2021/8855248. eCollection 2021. PMID: 33748281 

11. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Klionsky DJ, el al., Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 8. PMID: 33634751

12. Design, synthesis, and evaluation of Bothrops venom serine protease peptidic inhibitors. da Silva GM, de Souza DHB, Waitman KB, Ebram MC, Fessel MR, Zainescu IC, Portaro FC, Heras M, de Andrade SA. J Venom Anim Toxins Incl Trop Dis. 2021 Jan 15;27:e20200066. doi: 10.1590/1678-9199-JVATITD-2020-0066. eCollection 2021. PMID: 33488681 

13. Alterations of peripheral nerve excitability in an experimental autoimmune encephalomyelitis mouse model for multiple sclerosis. Teixeira NB, Picolo G, Giardini AC, Boumezbeur F, Pottier G, Kuhnast B, Servent D, Benoit E.J Neuroinflammation. 2020 Sep 7;17(1):266. doi: 10.1186/s12974-020-01936-9.PMID: 32894170

14. NFKF is a synthetic fragment derived from rat hemopressin that protects mice from neurodegeneration. Heimann AS, Giardini AC, Sant'Anna MB, Dos Santos NB, Gewehr MCF, Munhoz CD, Castro LM, Picolo G, Remer RA, Ferro ES. Neurosci Lett. 2020 Mar 16;721:134765. doi: 10.1016/j.neulet.2020.134765. Epub 2020 Jan 28. PMID: 32004656

15. Crotoxin down-modulates pro-inflammatory cells and alleviates pain on the MOG35-55-induced experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. Teixeira NB, Sant'Anna MB, Giardini AC, Araujo LP, Fonseca LA, Basso AS, Cury Y, Picolo G. Brain Behav Immun. 2020 Feb;84:253-268. doi: 10.1016/j.bbi.2019.12.009. Epub 2019 Dec 13. PMID: 31843645 

16. The Crotoxin:SBA-15 Complex Down-Regulates the Incidence and Intensity of Experimental Autoimmune Encephalomyelitis Through Peripheral and Central Actions. Sant'Anna MB, Giardini AC, Ribeiro MAC, Lopes FSR, Teixeira NB, Kimura LF, Bufalo MC, Ribeiro OG, Borrego A, Cabrera WHK, Ferreira JCB, Zambelli VO, Sant'Anna OA, Picolo G.Front Immunol. 2020 Oct 28;11:591563. doi: 10.3389/fimmu.2020.591563. eCollection 2020. PMID: 33193433

17. Early exposure to environmental enrichment protects male rats against neuropathic pain development after nerve injury. Kimura LF, Sant'Anna MB, Zambelli VO, Giardini AC, Jared SGS, Antoniazzi MM, Mattaraia VGM, Pagano RL, Picolo G. Exp Neurol. 2020 Oct;332:113390. doi: 10.1016/j.expneurol.2020.113390. Epub 2020 Jun 27. PMID: 32598929

18. Mitochondrially-targeted treatment strategies.Bozi LHM, Campos JC, Zambelli VO, Ferreira ND, Ferreira JCB.Mol Aspects Med. 2020 Feb;71:100836. doi: 10.1016/j.mam.2019.100836. Epub 2019 Dec 19. PMID: 31866004 

19. Mitogen-Activated Protein Kinase Signaling Mediates Morphine Induced-Delayed Hyperalgesia.de Freitas BG, Pereira LM, Santa-Cecília FV, Hösch NG, Picolo G, Cury Y, Zambelli VO. Front Neurosci. 2019 Sep 20;13:1018. doi: 10.3389/fnins.2019.01018. eCollection 2019. PMID: 31616243 

20. Crotoxin Conjugated to SBA-15 Nanostructured Mesoporous Silica Induces Long-Last Analgesic Effect in the Neuropathic Pain Model in Mice. Sant'Anna MB, Lopes FSR, Kimura LF, Giardini AC, Sant'Anna OA, Picolo G. Toxins (Basel). 2019 Nov 20;11(12):679. doi: 10.3390/toxins11120679. PMID: 31757011 

21. Advanced glycation endproducts produced by in vitro glycation of type I collagen modulate the functional and secretory behavior of dorsal root ganglion cells cultivated in two-dimensional system. Bufalo MC, Almeida ME, Franca IA, Zambelli VO, Martins Sant'anna MB, Kimura LF, Giardini AC, Cury Y, Sampaio SC. Exp Cell Res. 2019 Sep 15;382(2):111475. doi: 10.1016/j.yexcr.2019.06.020. Epub 2019 Jun 27. PMID: 31255600

22. Capsaicin-like analogue induced selective apoptosis in A2058 melanoma cells: Design, synthesis and molecular modeling. Pereira GJV, Tavares MT, Azevedo RA, Martins BB, Cunha MR, Bhardwaj R, Cury Y, Zambelli VO, Barbosa EG, Hediger MA, Parise-Filho R. Bioorg Med Chem. 2019 Jul 1;27(13):2893-2904. doi: 10.1016/j.bmc.2019.05.020. Epub 2019 May 14. PMID: 31104785.

23. Distinct environmental enrichment protocols reduce anxiety but differentially modulate pain sensitivity in rats. Kimura LF, Mattaraia VGM, Picolo G. Behav Brain Res. 2019 May 17;364:442-446. doi: 10.1016/j.bbr.2017.11.012. Epub 2017 Nov 11. PMID: 29137946.

24. Exercise Increases Insulin Sensitivity and Skeletal Muscle AMPK Expression in Systemic Lupus Erythematosus: A Randomized Controlled Trial. Benatti FB, Miyake CNH, Dantas WS, Zambelli VO, Shinjo SK, Pereira RMR, Silva MER, Sá-Pinto AL, Borba E, Bonfá E, Gualano B. Front Immunol. 2018 Apr 27;9:906. doi: 10.3389/fimmu.2018.00906. eCollection 2018. PMID: 29755474.

25. Pharmacological characterization of crotamine effects on mice hind limb paralysis employing both ex vivo and in vivo assays: Insights into the involvement of voltage-gated ion channels in the crotamine action on skeletal muscles. Lima SC, Porta LC, Lima ÁDC, Campeiro JD, Meurer Y, Teixeira NB, Duarte T, Oliveira EB, Picolo G, Godinho RO, Silva RH, Hayashi MAF. PLoS Negl Trop Dis. 2018 Aug 6;12(8):e0006700. doi: 10.1371/journal.pntd.0006700. eCollection 2018 Aug. PMID: 30080908.

26. 18F-Fluoride PET/CT and 99mTc-MDP SPECT/CT can detect bone cancer at early stage in rodents. Alves CRR, Faria DP, Carneiro CG, Garcez AT, Gutierrez VP, das Neves W, de Almeida NR, Cury Y, Chammas R, Brum PC. Life Sci. 2018 Aug 1;206:29-34. doi: 10.1016/j.lfs.2018.05.030. Epub 2018 May 17. PMID: 29778807.

27. Potamotrygon motoro stingray venom induces both neurogenic and inflammatory pain behavior in rodents. Kimura LF, Santos-Neto M, Barbaro KC, Picolo G. Toxicon. 2018 Aug;150:168-174. doi: 10.1016/j.toxicon.2018.05.018. Epub 2018 May 25. PMID: 29803862.

28. Articular inflammation induced by an enzymatically-inactive Lys49 phospholipase A2: activation of endogenous phospholipases contributes to the pronociceptive effect. Dias RG, Sampaio SC, Sant'Anna MB, Cunha FQ, Gutiérrez JM, Lomonte B, Cury Y, Picolo G.J Venom Anim Toxins Incl Trop Dis. 2017 Mar 23;23:18. doi: 10.1186/s40409-017-0104-0. eCollection 2017. PMID: 28344594.

29. Crotalphine desensitizes TRPA1 ion channels to alleviate inflammatory hyperalgesia. Bressan E, Touska F, Vetter I, Kistner K, Kichko TI, Teixeira NB, Picolo G, Cury Y, Lewis RJ, Fischer MJM, Zimmermann K, Reeh PW. Pain. 2016 Nov;157(11):2504-2516. doi: 10.1097/j.pain.0000000000000669. PMID: 27434506.

30. Secreted Phospholipases A₂ from Animal Venoms in Pain and Analgesia. Zambelli VO, Picolo G, Fernandes CAH, Fontes MRM, Cury Y. Toxins (Basel). 2017 Dec 19;9(12):406. doi: 10.3390/toxins9120406. PMID: 29311537.

31. Crotoxin, a rattlesnake toxin, down-modulates functions of bone marrow neutrophils and impairs the Syk-GTPase pathway. Lima TS, Neves CL, Zambelli VO, Lopes FSR, Sampaio SC, Cirillo MC. Toxicon. 2017 Sep 15;136:44-55. doi: 10.1016/j.toxicon.2017.07.002. Epub 2017 Jul 5. PMID: 28688804.

32. Exercise reestablishes autophagic flux and mitochondrial quality control in heart failure. Campos JC, Queliconi BB, Bozi LHM, Bechara LRG, Dourado PMM, Andres AM, Jannig PR, Gomes KMS, Zambelli VO, Rocha-Resende C, Guatimosim S, Brum PC, Mochly-Rosen D, Gottlieb RA, Kowaltowski AJ, Ferreira JCB. Autophagy. 2017 Aug 3;13(8):1304-1317. doi: 10.1080/15548627.2017.1325062. PMID: 28598232.

33. Increased Insulin Resistance and Glucagon Levels in Mild/Inactive Systemic Lupus Erythematosus Patients Despite Normal Glucose Tolerance. Miyake CNH, Gualano B, Dantas WS, Pereira RT, Neves W, Zambelli VO, Shinjo SK, Pereira RM, Silva ER, Sá-Pinto AL, Borba E, Roschel H, Bonfá E, Benatti FB. Arthritis Care Res (Hoboken). 2018 Jan;70(1):114-124. doi: 10.1002/acr.23237. Epub 2017 Dec 6. PMID: 28320046.

34. Structural determinants of the hyperalgesic activity of myotoxic Lys49-phospholipase A2. Zambelli VO, Chioato L, Gutierrez VP, Ward RJ, Cury Y. J Venom Anim Toxins Incl Trop Dis. 2017 Feb 10;23:7. doi: 10.1186/s40409-017-0099-6. eCollection 2017. PMID: 28203248.

35. Peripheral 5-HT3 Receptors Are Involved in the Antinociceptive Effect of Bunodosine 391.Ferreira Junior WA, Zaharenko AJ, Kazuma K, Picolo G, Gutierrez VP, de Freitas JC, Konno K, Cury Y. Toxins (Basel). 2017 Dec 27;10(1):12. doi: 10.3390/toxins10010012.PMID: 29280949.

36. Harnessing the knowledge of animal toxins to generate drugs. Zambelli VO, Pasqualoto KF, Picolo G, Chudzinski-Tavassi AM, Cury Y. Pharmacol Res. 2016 Oct;112:30-36. doi: 10.1016/j.phrs.2016.01.009. Epub 2016 Jan 27.PMID: 26826284.